There is a big difference.

这是一个重要的区别。

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But there is a big difference. Television was programmed and inflexible.

但其中的巨大差别在于，电视是经过编排的，而且无法自主选择。

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There is a big difference in the amounts that banks charge.

各个银行在收费数额上有很大差异。

《柯林斯英汉双解大词典》

There is a big difference this year.

VOA: special.2010.03.01

I think there is a big difference.

有很大的不同。

圣莫妮卡的海滩 - SpeakingMax英语口语达人

And there is a very big difference between these two simplicities, even though on the face of it, they may at times look similar.

这两种简单性之间有很大的区别，尽管乍看起来，他们有时也许是相似的。

哈佛公开课 - 幸福课课程节选

Actually, though, there is a big difference.

FORBES: Low-Priced Semiconductor Buys

There is a big difference.

FORBES: Why China Does Green Tech The Right Way

The CDU and FDP vow to relieve these ailments but there is a big difference between them.

ECONOMIST: Tax cuts emerge as a central issue in the election campaign